Interleukins 12 and 13 levels among beta-thalassaemia major patients
نویسندگان
چکیده
منابع مشابه
Interleukins 12 and 13 levels among beta-thalassaemia major patients.
The role of inflammatory cytokines in the pathophysiology of beta-thalassaemia is still unclear. In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells-from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. ...
متن کاملIron overload in Beta thalassaemia major and intermedia patients.
ABSTRACT BACKGROUND In beta thalassaemia major multiple blood transfusions, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body. Iron overload impairs the immune system, placing patients at greater risk of infection and illness. Iron overload can be determined by serum ferritin measurement. OBJECTIVE The aim of the present study is to...
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Dear Madam, Beta thalassaemia is the most common inherited disorder in Pakistan. It is estimated that over 4000 thalassaemia children are born in Pakistan each year. As thalassaemics are among the most transfused patients and therefore are most exposed to transfusion transmitted infections, all these patients usually receive multiple blood tmnsfusions which in most cases are not screened or scr...
متن کاملPrevalence of hepatitis B infection in beta thalassaemia major patients.
Madam, Beta thalassaemia major is a common genetic disorder in the country and hepatitis B and C viruses are prevalent in the blood donors population. therefore, patients with beta thalassaemia major who receive blood transfusions regularly to maintain optimal Hb level frequently suffer from the hepatitis infection. An earlier study has shown 51% prevalence of hepatitis C infection among them. ...
متن کاملPlatelet function in beta-thalassaemia major.
Abnormal platelet aggregation was found in eight (44%) of 18 patients with beta-thalassaemia major and transfusional iron overload. The aggregation defect bore no correlation with the degree of hepatic fibrosis, liver function tests, whether or not splenectomy had been performed, the degree of iron overload, haematocrit, platelet count, serum vitamin E level, or leucocyte ascorbate concentratio...
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ژورنال
عنوان ژورنال: Eastern Mediterranean Health Journal
سال: 2013
ISSN: 1020-3397,1687-1634
DOI: 10.26719/2013.19.2.181